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GDC-0349 was orally dosed to mice at 30-80 mg/kg once per day
CAS Number: 121123-17-9
InChiKey: JOKVJNCYOSFDGC-LJAQVGFWSA-N
214(2):258-64
D609 - CAS# 83373-60-8 tin-3'-sulfonate GDC-0349 was orally dosed toD 609, also known as D 609 free, is a phospholipase C inhibitor potentially for the treatment of pancreatic cancer. D 609, an inhibitor of PC PLC and sphingomyelin synthase, strongly inhibited myogenic tone and had no effect on depolarization induced contraction. D 609 appeared to act by lowering cytoplasmic Ca(2+) concentration to levels below those that activate contraction. Product information CAS Number: 83373 60 8 Molecular Weight: 266. 46
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