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is a 5-HT1D antagonist with Ki of 249 nM
a chemical probe targeting the bromodomains of BAZ2A and BAZ2B
Greenhough S
PRMT6 and PRMT8
Pyridostatin TFA salt - CAS# 1085412-37-8 167 is a 5-HT1D antagonist withPyridostatin, CAS No. 1085412 37 8, stabilizes G quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication and transcription dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G quadruplex formation. As a result, pyridostatin modulated the expression
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