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CAS Number: 157716-52-4
Formula: C24H30N8O
InChi: InChI=1S/C18H24N2O3S
7-fold to 5
GDC-0032 Size:Solid 2 mg CAS Number: 157716-52-4Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0. 2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC 0032 preferentially inhibited PIK3CA
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