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27)/t17-/m1/s1
and potential antineoplastic properties
while A 419259 blocks kinase activation between 0
InChi: InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13
(R)-5-Hydroxymethyl Tolterodine 2 inhibitor 1 27)/t17-/m1/s1Desfesoterodine, also known as PNU 200577, is a major pharmacologically active metabolite of tolterodine, a new muscarinic receptor antagonist intended for the treatment of an overactive bladder. In vitro, PNU 200577 produced a competitive and concentration dependent inhibition of carbachol induced contraction of guinea pig isolated urinary bladder strips (KB = 0. 84 nM; pA2 = 9. 14). In vivo, PNU 200577 was significantly more potent at inhibiting
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