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WAY-600 dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells
by 90% within 1 hour
Smiles: CCC1=CC=CC=C1OC[C@@H](O)CN[C@H]1CCCC2=CC=CC=C21
InChi: InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7
YM 254890 Size:2mg solid WAY-600 dose-dependently increases the activityG protein inhibitor. Potently inhibits Gq 11 heterotrimeric G protein signaling. Inhibits ATP UTP induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP induced Ca2+ increase in platelets, in vitro (IC50 = 2 M). Also inhibits Gs induced cAMP elevation and G protein coupled MAPK ERK signaling. Product information CAS Number: 568580 02 9