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CAS Number: 916918-84-8
its monophosphate form inhibits thymidylate synthase
InChiKey: LXENKEWVEVKKGV-BQYQJAHWSA-N
InChiKey: CPMGENCTAWBLNW-UHFFFAOYSA-N
JLK 6 njugates 15 hydrochloride CAS Number: 916918-84-8JLK 6, an isocoumarin, is a selective inhibitor of secretase, with an IC50 value between 10 M 1 mM [1, 2]. The enzyme secretase catalyzes the cleavage of Amyloid precursor protein (APP) to produce Amyloid peptide (A). A is a part of the plaque present in the brain of patients with Alzheimers disease. secretase also targets other substrates like Notch. Notch is a transmembrane protein which is involved in important functions during different stages in