(S)-crizotinib - MTH1 Inhibitor. CAS# 1374356-45-2 002 Actin-dependent Regulator of Chromatin (SMARC)

Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin

(S)-crizotinib - MTH1 Inhibitor. CAS# 1374356-45-2 002 Actin-dependent Regulator of Chromatin (SMARC)(S) Crizotinib, CAS No. 1374356 45 2, is a novel potent, selective and cell permeable MTH1 inhibitor with an IC50 of ~72 nM. MTH1 is a nucleotide pool sanitizing enzyme. (S) Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition and induces an increase in DNA single strand breaks in cancer cells. In vivo it can effectively suppress tumor growth in colon carcinoma xenograft model by once per day oral dosing. (R) Crizotinib, which is (R)